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question from a user

1. Have you noticed any difference clinically in daily subcutaneous dosing compared to weekly or twice weekly IM dosing, assuming the weekly dose is equal? Have always been curious if smaller daily doses triggered less endogenous suppression compared to intermittent larger doses. 2. Is it a reasonable request to begin TRT treatment with HCG treatment for the pure reason of avoiding testicular atrophy? (Not because of wanting to reproduce, just a desire for the anatomy to not atrophy visually).

AlphaMD's Answer

  • Yep, there's a real difference between the two. In general though, this difference only matters if someone has a high transfer rate to Estrogen, otherwise it's just preference. When it comes to suppression there's not much of a change, if you're on TRT you're going to be suppressed pretty dang well either way. However the lower daily doses (and the fact that Subq absorbs slower into the bosy) does result in lower spikes & less transfer to E.

  • This is fine. We typically advise people to avoid extra HCG unless they're having a child due to the cost & that it's mostly cosmetic otherwise. If you know you want it for cosmetic reasons & you're fine paying the extra cost, rock on, you know what you want.

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