Back to all Questions

question from a user

Any experience of managing trt that is also supplemented by the individual with 4 Androstenediol. I use 2 squirts of Testogel daily but feel it doesn't last 24hrs (will soon have blood results to confirm or not) so I supplement with a 125mg tablet of 4 Androstenediol in the late afternoon (was going to do an additional blood test 2hrs after this at some point to measure impact).

AlphaMD's Answer

4 Androstenediol

4 androstenediol does two things, it weakly attaches to the androgen receptor directly, and it also converts into other sex hormones.

4 androstenediol converts into estrogen and testosterone, at a rate of close to 15%. This means that it will only raise the testosterone levels slightly. In someone who is already on TRT, it will not raise T levels to any significant degree.

More importantly, because the remaining 85% of it attaches to the androgen receptor itself it has some androgenic effect, however, it is a weak partial agonist, meaning that its attachment is loose and so its effect is not as robust as testosterone or DHT. In the presence of other stronger receptor agonists like T and DHT, it actually acts as an antiandrogen (it takes up the receptor site, preventing the more effective androgens from attaching and doing a better job).

There is a reason that you don't hear of people taking 4 androstenediol with TRT. That is because will only work against your TRT, and actually make it less effective.

Ready to get answers?
Ask your own question today.

Get $30 off your first month’s order

Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.

Legal Disclaimer

This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.