question from a user
Any experience of managing trt that is also supplemented by the individual with 4 Androstenediol. I use 2 squirts of Testogel daily but feel it doesn't last 24hrs (will soon have blood results to confirm or not) so I supplement with a 125mg tablet of 4 Androstenediol in the late afternoon (was going to do an additional blood test 2hrs after this at some point to measure impact).
AlphaMD's Answer
4 Androstenediol
4 androstenediol does two things, it weakly attaches to the androgen receptor directly, and it also converts into other sex hormones.
4 androstenediol converts into estrogen and testosterone, at a rate of close to 15%. This means that it will only raise the testosterone levels slightly. In someone who is already on TRT, it will not raise T levels to any significant degree.
More importantly, because the remaining 85% of it attaches to the androgen receptor itself it has some androgenic effect, however, it is a weak partial agonist, meaning that its attachment is loose and so its effect is not as robust as testosterone or DHT. In the presence of other stronger receptor agonists like T and DHT, it actually acts as an antiandrogen (it takes up the receptor site, preventing the more effective androgens from attaching and doing a better job).
There is a reason that you don't hear of people taking 4 androstenediol with TRT. That is because will only work against your TRT, and actually make it less effective.
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