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question from a user

Any idea why I would be constantly buzzed/wired on a low dose of 80/wk every day subq? What percentage of your guys are subq vs IM?

AlphaMD's Answer

  1. I can't say. While TRT often resolves fatigue, it is not known to make someone feel "wired". We have had some men report this phenomenon, but it seems to occur primarily when first starting TRT and resolves with time. I believe that this occurs because, although a lot of people don't know this, approx 15-20% of testosterone is produced by the adrenal glands, which also produce adrenaline. In some men who were hypogonadal, their testicles failed, so the adrenal glands basically had to take up the slack and work harder to produce more and more testosterone. Then when TRT is started, the adrenals no longer are pressured to produce testosterone, so they go back to producing adrenaline. But they are still "amped up" from working so hard to make the T, that they overproduce adrenaline for awhile.

  2. The majority of our patients prefer SQ. Probably 85-90%.

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