question from a user
Asking for a friend, on compound biest 50/50 with T .topi click with a 4/4/5 dose . E2 70 ish, total T 27 in trough but free T like 0.2 shbg high 90’s. P is like 1.2 . Why would they tell her her E2 was too high and drop the dose nearly 25 percent on everything but the progesterone. Actually raised it to 200 a day . She tried this and it has crashed her hormones back to her post menopause levels .
AlphaMD's Answer
It seems like your friend’s doctor is basing treatment off of the progesterone/estradiol ratio. In normal menstruating women, the P/E2 ratio is typically between 200-400. Clearly your friend falls well outside of this based on the numbers you listed. By raising the progesterone dose and lowering everything else, it is clear her doctor is trying to adhere to this ratio.The thing is, the P/E2 ratio only matters in menstruating women. It has no bearing whatsoever in women who are menopausal.If your friend felt good with that previous treatment, then there is no reason at all that any changes need to have been made.
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