question from a user

Can a small dose of trt (50 to 80 ml) weekly and small dose of enclomiphene (not clomid) be used? The reason for the enclomiphene is to keep a small number of my production going. Some people say it's useless the only reason would be to keep other hormones that the testosterone produce (pregnenolone, dhea etc)

AlphaMD's Answer

A dose of 50-80 mg (I'm assuming you meant that as opposed to mL) weekly is a dose that likely would typically get most men only to a level in the low 400s (a simple rule is that most men will convert 1mg of injected testosterone to between 4-6 ng/dL. So a man injecting 50-80 mg could expect anywhere from a level of 200 mg/dL to 480 ng/dL. These levels are below normal or low normal. Since testosterone injections suppress normal testosterone production, a dose this low would do nothing except shut you down and likely give you a T level at or below your baseline level anyways.

Adding enclomiphene, increases natural production of T by increasing both FSH and LH. There are no reliable studies that have paired TRT along with clomid or enclomiphene. But logically, adding one of these to TRT would at the very least help you maintain your fertility and the level of natural T you were to produce at your baseline.

Remember that most men have primary hypogonadism, which means the function of the testicles has failed. This means all the enclomiphene in the world won't raise your T levels by much. If enclomiphene does raise your T levels, then you likely suffer from secondary hypogonadism due to a pituitary disorder.

So, putting all that together: all you would do by taking a low dose of testosterone is shut down your natural production completely, and adding enclomiphene would restart your testicles to produce the same level they were producing before you started T. So you could basically add the 2 T levels (your natural production before TRT and your current T dose) together.

For example, say your natural T level before TRT was 250. You take 50 mg/wk of exogenous testosterone and convert it to 6 ng/dL = 300 ng/dL.

250 + 300 = 550 ng/dL.

While this level may be better than the 250 you were at before, it is likely not high enough to relieve the symptoms of hypogonadism.

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