question from a user

Do you believe Tamoxifen is necessary? I see people always saying there's not point taking 2 SERMs at once, but even well informed people like Vigorous Steve recommend it in pct.

AlphaMD's Answer

This has been studied, and there is no benefit in being on two SERMs at the same time. SERMs are partial antagonists that have differing estrogenic and antiestrogenic in different tissues. Clomiphene and tamoxifen have almost identical estrogenic/antiestrogenic profiles. It would make more sense adding raloxifene to clomiphene, which has a different profile than clomiphene. But being on both tamoxifen and clomiphene only increases side effects without additional benefits.

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