Back to all Questions

question from a user

Do you have any theories as to why some people experience a honeymoon phase for a few weeks then lose the benefits of TRT?

AlphaMD's Answer


The most common reason for this in men tends to be a need for a simple dose adjustment. There's a general 8 week uptake period where injected levels increase week over week & then natural production tends to slow down/stop. Around the week 3-5 marks, two things can happen. The first is that the injected Testosterone & the natural Testosterone together hit a mark that your body sees as ideal, then the natural continues to fall off. In that case a simple increase of 10-20mg tends to return you to that point & we consider that very normal & part of dialing you in. The second can be that you experience the above, but that it's too much Testosterone together & so you transition additional Testosterone into Estrogen during this time. If it's just that, then this should go away when the natural production slows & it is important to not over react during this time and increase an AI, when it may be overkill later. If it doesn't improve by weeks 7-8 & you have consistent high Estrogen symptoms then adding or increasing an AI slightly or lowering your Testosterone dose slightly tends to fix things. Somewhere between 20-30% of men need some kind of adjustment around the 7-8 week mark for those reasons.

Ready to get answers?
Ask your own question today.

Get $30 off your first month’s order

Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.

Legal Disclaimer

This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.