question from a user
Does testosterone ever lose its efficacy…. If you’re on 200mg/ week for 1.5-2 years then come off for a year.. then go back on same dose… is it less powerful or lose its efficacy since there’s not “virgin androgen receptors”
AlphaMD's Answer
Some medicines can develop what is known as tachyphylaxis, which is fancy medical speak for becoming less potent over time. Interestingly, testosterone has never been proven to develop this problem, likely because it is a bio-identical hormone and not a medicine in the true sense of the word.
You can be on TRT for 20 years, and never need to change your dose. Coming off and then restarting will have no effect on the androgen receptors since their sensitivity remains the same over time.
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