question from a user
Endo has me on clomid and trt. Would they switch me to hcg instead? Is it better to use than clomid?
AlphaMD's Answer
The SERM (clomiphene or enclomiphene) and TRT combo is still experimental and not proven science. The hCG plus TRT is proven and the gold standard for men on TRT who want to maintain fertility.
While the there is logic to the theory behind why a SERM like Clomid might work while concurrently on TRT, we have no good studies proving that.
We do know that clomiphene and enclomiphene both have a higher side effect profile than hCG. We also know the both clomiphene and enclomiphene cause shutdown of the body’s production of IGF-1, a hormone which has greater benefit for muscle growth and fat loss than even testosterone.
Basically, our thought is hCG is proven to use while on TRT, and is available with lower side effects. We know some doctors have had trouble sourcing it from reputable FDA approved pharmacies, prompting them to instead prescribe Clomid, though all of AlphaMD’s partnered pharmacies have it available in all states.
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