Arimistane should not be considered an aromatase inhibitor in the traditional sense. Unlike medications like anastrozole or letrozole, which block aromatase, but releases it several days later, Arimistane is a suicide medication, meaning it literally destroys aromatase. The problem with that is without any aromatase, you literally have no estrogen. Aromatase enzyme is necessary to create any estrogen in the body. The two routes to estrogen (androstenedione —> estrone; testosterone—> estradiol) both require aromatase. Estrogen is needed for many beneficial health effects. You risk dropping your estrogen too low with Arimistane, and unlike traditional AI’s it often takes weeks or longer to recover because your body has to make a whole new supply or aromatase before your body can produce more estrogen.

So with that in mind, I can tell you that it works in lowering estradiol, but many would tell you it works too well.

Also, I’m not sure where you live, but Arimistane is typically around $70/mo. Here (in the US) you can get a year supply of anastrozole for about $30-40 without insurance.

As for DIM...It works. We have definitely seen it work. It is natural (an extract of foods). It is safe. The only problem is that it is a supplement, so it is not FDA regulated so you don’t know what you are getting. 1 in 3 supplements are fake, and of those that aren’t, 60% don’t have the actual amount of the active ingredient they say they do. For that reason, all we can say is do your research about different brands and buy from a reputable source