question from a user
Hi! I’m doing HCG mono 3500 UI / week. 3 mg Anastro / week and 50mg clomi 3x / week. My T is at 1050 and E2 at 39. Without anastro I was with 90 E2 feeling really bad. Right now I struggle with inconstant libido, don’t know if E2 is still too high. I have felt better when we have lower my estrogen from 90 to 60 and then to 40. But I feel I’m taking too much anastro, and I don’t think I’ve dialed in perfectly.
AlphaMD's Answer
That is indeed a very high dose of anastrozole.
So, a few thoughts about your protocol:
Clomid triggers natural production of LH, whereas hCG is an LH analog. Both of these medicines compete for the same receptor. That means one will cancel out the other (LH has stronger binding affinity than hCG, so the hCG loses in this battle). Taking both has never been proven to be more beneficial than just taking one or the other.
This means that most of the hCG is wasted and will only contribute to side effects, like high estradiol.
TL;DR: HCG works on its own. Clomid works on its own. HCG and Clomid do not work together, they compete for the attention of the same receptor.
Talk to your doctor, but if you were my patient, I would recommend dropping the hCG completely.
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