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How to increase IGF levels if I’m taking enclomiphene as my TRT?

AlphaMD's Answer

Enclomiphene has the distinct feature of decreasing IGF-1 production. Here is a study that discusses it further.

The science suggests that it shuts down the process that manufactures IGF-1, which means it will prevent any increase that would normally be expected when using injections of exogenous testosterone.

Essentially, any efforts to raise IGF-1 will not be effective while on enclomiphene because it blocks the internal mechanism that elevates it in the first place.

For this reason, if fitness/physique are your primary goals in raising your testosterone, enclomiphene is the least effective method to accomplish this.

https://aacrjournals.org/cancerres/article/73/8_Supplement/1326/586892/Abstract-1326-Oral-enclomiphene-citrate-lowers-IGF#

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