question from a user
I did semaglutide and had terrible nausea while on it. Is it the same for Tirzepatoide?
AlphaMD's Answer
They are similar & there is something of a shared tolerance build up between them when switching between the two. However you can think of tirzepatide as the next gen of semaglutide - It's more effective with less side effects, but more expensive.
While semaglutide attaches to the GLP-1 receptors, tirzepatide attaches to both GLP-1 and GIP receptors, so it has a stronger effect by working through a second pathway which semaglutide does not. You may find that your side effects on it are less severe than with semaglutide because you may get adequate weight loss without needing to escalate the dose as much.
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