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question from a user

I have chronically low SHBG and TRT hasn't changed this. All other blood markers are okay. Have you seen this before or have any information on it?

AlphaMD's Answer

There are many things that can effect SHBG levels. Body fat percentage, alcohol intake, vitamin D levels, problems with insulin levels or the thyroid, and even your diet. Typically, as sex hormone levels go up, so does SHBG to act as a buffer. However, provided your levels never exceed your body's set limit of what it considers normal, your liver will have no reason to create more SHBG. If you are on a reasonable dose of TRT, and don't inject supraphysiologic levels, then you won't trigger your liver to produce more SHBG and it will remain the same.

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