question from a user
I have very low SHBG (below reference range). What do you recommend clients with low SHBG? And is it an indicator of poor health?
AlphaMD's Answer
Low SHBG itself is not a bad thing. But, low SHBG is an indicator for some medical conditions that can be bad. Cancer lowers SHBG. It’s the cancer that is bad, not the low SHBG. Hypothyroidism can lower SHBG. It’s the hypothyroid that cause problems, not the low SHBG. Diabetes causes low SHBG. You get the picture.
You never need to do anything about low SHBG because low SHBG is not an unhealthy thing to have. You do need to evaluate WHY you have low SHBG as the things that cause it to be low can be bad.
In the setting of TRT, low SHBG generally just means your testosterone is more effective because there is less to bind to your testosterone.
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