question from a user
I take 250 units every other day, so about 750 per week, because I heard that a lower dose wouldn't be as effective in maintaining testicular size. Doses below 750 per week are said to be ineffective and a waste of money. What is your experience with this?In my case, fertility is even undesirable. I prefer to remain sterile but keep testicular size while on TRT
AlphaMD's Answer
750IU/wk = ~ 93% of baseline testicular function while on TRT.
Doses below 750IU are absolutely effective, but to what degree hasn’t been quantified as closely as 750IU was the lowest dose in the studies measuring ITT.
However, if 750IU overcomes more than 90% of the shutdown that occurs with TRT, then by that logic 325IU should get a patient to about 45% of baseline testicular function. That feasibly should be enough to prevent significant atrophy in most men.
There are no absolutes in medicine, because everyone is unique. We have had plenty of patients in our practice who have sperm counts in the tens of millions on 500IU/wk. Your response may be entirely different though.
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