The process of creating estrogen is the same in women as it is in men. Women actually produce more testosterone than estrogen in their lives. They produce testosterone first and then convert it to estrogen through the aromatase enzyme. A woman with low testosterone typically will have low estradiol (unless she has an aromatase deficiency, which is rare).Giving testosterone to a woman will raise their estrogen. Always. It will also raise their estrogen more than it will raise their testosterone (unless you give too much, which will saturate and then overwhelm their aromatase reserve).Progesterone is a precursor hormone that actually found on the aldosterone/cortisol side of the sex hormone cascade. This means that while it is possible for TRT to suppress progesterone production, it is typically not affected to any significant degree. If it is affected, a simple solution is to add the supplement pregnenolone (over the counter, $5-8/mo cost). Pregnenolone is converted into progesterone.All of this is to preface the answer to your question: does she need to take estrogen and progesterone or can she just take hrt?Most women only need to take a low dose of testosterone. Their body will naturally produce estrogen from that testosterone. It should not affect her progesterone production, and if it does, taking OTC pregnenolone will resolve that issue. She does not need to take estrogen or progesterone.In our practice, about 80% of women on HRT only take testosterone. Of those, about 25% also supplement with pregnenolone.