I've just started TRT. My SHBG is 55 nmol/l (normal range: 18 to 40 nmol/l). Will injecting cypinate M/W/F, subq, at 132mg a week, lower my SHBG? And if so, by how much roughly and how long will it roughly take?

Each person's response to TRT is entirely different. This is why there is typically some trial and error involved in the dosing, injection schedule, and potential need for ancillary medications (like an AI).

With that in mind, I cannot say to what degree your body will respond to that dose, or how much your liver will respond by creating SHBG. But I will give you these general principles:

1. The average man converts 1mg of exogenous testosterone into about 6.5 ng/dL of total testosterone. So the typical man on 100mg/wk would have a TT of 650 ng/dL (average, not peak or trough). Obviously some get more or less than this conversion, but this is average. We cannot tell you what the average free T will be on any given dose because of the drastic individual variability of SHBG.

2. The higher a dose of T taken at any given time will typically result in your liver creating more SHBG. This means taking more frequent (daily) smaller doses will not trigger the liver to produce more SHBG, resulting in a higher free T level at the same weekly dose.

3. Avoiding alcohol, taking vitamin D (or getting adequate sun exposure), supplementing with magnesium and boron, and taking fish oil or krill oil will lower your SHBG.