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Is there any disadvantage to HCG monotherapy as opposed to TRT?

AlphaMD's Answer

  1. Tachyphlaxis. This is the medical term for drug failure. HCG has been proven to cause downregulation (desensitization) of the LH receptors over time. This means that the longer you use hCG, the less effective that dose becomes. You need to raise the dose over time to get the same effects (similar to heroin on opiate receptors).

  2. Cost. HCG is perhaps the most expensive medicine in the men’s health toolbox. Due to regulatory issues, it has become much more limited in supply, and as more and more young men are seeking treatment for hypogonadism, demand is at an all time high.

  3. Aromatization. HCG aromatizes at a much higher rate than testosterone. This means many/most men on hCG monotherapy will require an aromatase inhibitor to try to avoid the side effects of high estrogen.

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