question from a user
My female friend is like a zombie most mornings now . She was having symptom relief back in October/ November . Her test levels went to 189 4 hours after cream application and the best at trough was 27 but no energy or libido at those levels. Her free T has always been on the very bottom no matter the dose. She has a doctor appointment Wednesday with blood work so maybe they will come up with something. This has been going on 10 months. I’m trying to talk her into using an online hrt clinic that specializes in hormones for women. I have never heard of anyone dropping doses . What gets me is when they done that her p level was based on 100 mg a day but the lowered her e2 and test and raised her p to 200
AlphaMD's Answer
The half-life of the topical forms of testosterone are short. For the gel the half life varies widely, between 10-100 minutes, with an average of just over an hour. The half-life of the topical creams is similar. She will have low testosterone 24 hours after her last dose. In cases like this where she wakes up feeling symptomatic, she could consider a second dose in the evening. However, a better option for her would likely be injections. The half-life of testosterone cypionate is 8 days as opposed to a few hours with the cream. This means her levels will remain therapeutic longer, with fewer doses needed.
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