question from a user
My PCP thankfully scripts my TRT but I'm curious about your take on injection regimens. Are ED injections, in lieu of EOD injections, more efficacious in terms of E2 management or does the Testosterone being bound in the Cypionate ester more or less make such a routine pointless overreaction. Upvote 3 Downvote Award Share Share
AlphaMD's Answer
Short answer: Yes this approach is typically better to manage Estrogen issues.
Long answer: If your total weekly Testosterone injections & your resulting overall level are causing transfer then doing it more often isn't going to help, taking a bit more AI might. However if you are transferring hormones only due to your body seeing the spike in Testosterone which does occur with injections (including Cypionate) then dosing more frequently at a lower dose will cause less spikes & your body may not need an AI at all.
For reference, we typically start someone on IM injections only twice weekly & most men do not need an AI at that frequency & therapeutic dosing. If we see Estrogen issues then we might switch to three times weekly or Subq three times weekly (as subq also slows absorption rates and thus spikes). We do have men on EOD or daily injections but it is because they have requested it themselves.
It is typically best to start spread out & then adjust down, as needle fatigue is a very real concern for regimen compliance.
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