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question from a user

My question is have you heard of Calcium D-glucarate being substituted instead of an AI? And reducing E levels? My Endo seems to know nothing about AI and I recently started adding hcg to the mix (250iu x2) per week. A popular YouTube fitness channel, recommended adding 25mg DHEA and 500mg calcium d x 2 per day to naturally decrease E levels have you heard of this? And any experience with it?

AlphaMD's Answer

Calcium D-glucarate has been shown to increase the metabolism of estrogen, meaning your body will eliminate it from your system faster. It does nothing to block the conversion of testosterone to estrogen like a traditional AI.Does it work to lower estrogen levels? There are conflicting studies but in general, it is sold in conjunction with DIM, which is a natural AI. The reduced aromatization of the DIM, and the faster excretion of E2 by the CD2 may work for some patients with only mildly elevated estradiol levels.

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