question from a user
Presuming I will be in this fight for a year or two… and I want to really really feel the libido and mood benefits of TRT… I can accept that I will have mid TT.. 2 questions should I slowly reduce weekly dose until my FT is under the top end of the ref range? I have to imagine that in general and especially in this case, high free hormones + low SHBG is probably diminishing returns? I’m okay with an AI for the time being, there is not much data on this particular issue, but looking at the fabled ratio. I would want to get my e2 down to 25-27 pg/ml…. Given adex halflife … would .5mg e3.5d make sense as a starting point?
AlphaMD's Answer
You will definitely have a much easier time dialing things in by following free T than following total T. Yes, you will want to get within the upper range for free T. At that range, you are likely not reaching peak saturation of androgen receptors, which means your body won’t be as likely to convert to E2 or DHT.
0.5mg twice a week is generally speaking a high dose for an AI. We typically recommend a once weekly dose, with the goal to have one of your shots blocked from conversion, and the other to allow some conversion so that way you are less likely to result in low E2. But as you mentioned, lowering your T dose will also help control your estrogen levels.
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