Back to all Questions

question from a user

Should I consider increasing/optimizing SHBG? Some mild symptoms of low SHBG but feel great for the most part. Before TRT: Testosterone: 371 Free T: 15.4 Estradiol: 38.6 SHBG: 21.3 TRT 12 months later (80mg x2 per week) Testosterone: 1150 Free T: 39.8 Estradiol: 54 SHBG: 12

AlphaMD's Answer

Once you have started TRT, SHBG loses a lot of its meaning because you can always adjust your regimen to overcome any problems you have with it.

Once sex hormones attach to SHBG, it completely inactivates that hormone for the remainder of its life.

Think of SHBG like a sponge. You won’t get any free T until you have saturated the SHBG sponge.

Another example is that SHBG is a pit you have to fill before any of your sex hormones become active. Some people have deeper pits than others.

Once on TRT, you can always increase or lower your dose depending on how big your sponge is.

You can adjust the size of your sponge by adjusting the dose or the frequency of injections (more frequent injections lowers SHBG).

Ready to get answers?
Ask your own question today.

Get $30 off your first month’s order

Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.

Legal Disclaimer

This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.