question from a user
So someone who is using 200mg vs someone who is using 100mg and both of their labs show ~1000 test levels irregardless of weight/fat that just means individually they are a worse/better responder /(aromatiser) to the extra test? It was mentioned that each person has the same number of androgen receptors so is there such a thing as androgen receptor efficiency or is it just some people convert test to e2 more then others? Any other reasons/mechanisms for the vastly difference doses with similar lab results?
AlphaMD's Answer
In our experience, it tends to just be very individual. Like your example, we have some men on 90mg/wk who have total Ty’s around 1000, and some men who need 200mg to get to the same level.
So yes, the “better responder” is a real phenomenon, and has nothing to do with adipose tissue. Some men are just lucky I guess.
While each individual man has the same receptors regardless of if they gain or lose weight, Each man has different numbers of total androgen receptors when compared to other men.
Think of them as locks on the door (cell). You can’t open the lock without the key (testosterone). Some men have 3 or 4 locks on their door, so they require 4 keys to open it. Some men only have one lock per door, so they do fine with fewer keys (ie lower testosterone levels).
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