question from a user
What are the benefits of DHEA with Testosterone?
AlphaMD's Answer
As of now, no DHEA receptor has been identified in the human body. That means that DHEA is solely a precursor to other sex hormones. Any DHEA you take will be converted to something else.
As you can see in the above image, DHEA converts into androstendione. This then can lead to testosterone production or estradiol. Because you already have enough testosterone on TRT, most DHEA that you add will convert to estradiol. While some men do ok with DHEA on TRT, it is not often beneficial. It typically only adds to side effects and runaway estradiol levels.
Anecdotally, some men get improved mood and libido on DHEA, but there are no studies showing benefits of adding DHEA while on TRT. If you do choose to take DHEA while on TRT, we recommend taking a low dose, and only every other day at most.
Related Questions
Currently my provider has paired TRT with DHEA. What is the benefit/risk of DHEA?...
Adding DHEA benefits: Helps with the downstream effects of creation of DHEA-S and androstendione. Both of which typically have positive effects on mood and cognition. Adding DHEA risks: Extra DHEA can... See Full Answer
Is there a benefit to adding DHEA to TRT?...
I would first consider your current DHEA levels. There can be benefit as it can support test production/levels and in a different pathway. This can improve energy and libido. However, DEAH with TRT ca... See Full Answer
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