In general it is fairly safe, and if you are suffering from low Testosterone & don't want your TRT to be in the form of Testosterone injections, it is a good alternative.

That is provided that you have secondary hypogonadism, as hCG monotherapy is useless in primary hypogonadism (testicular failure).

Compared to traditional TRT, there are some downsides:

1. Tachyphlaxis. This is the medical term for drug failure. HCG has been proven to cause downregulation (desensitization) of the LH receptors over time. This means that the longer you use hCG, the less effective that dose becomes. You need to raise the dose over time to get the same effects (similar to heroin on opiate receptors).

2. Cost. HCG is perhaps the most expensive medicine in the men’s health toolbox. Due to regulatory issues, it has become much more limited in supply, and as more and more young men are seeking treatment for hypogonadism, demand is at an all time high.

3. Aromatization. HCG aromatizes at a much higher rate than testosterone. This means many/most men on hCG monotherapy will require an aromatase inhibitor to try to avoid the side effects of high estrogen.

So while we would advise it over things like Clomid/Enclomiphene, or no treatment at all, Testosterone creams/Injections would still usually work better in the long run.

If the goal is fertility while on TRT, high dose HCG monotherapy is perfectly fine to provide more Testosterone while attempting conception rather than no TRT treatment. Most men on Testosterone tend to pair it with high dose HCG during conception attempts for this reason & the reasoning above, but do not stay at high doses forever.

As a monotherapy, 1000-2000 a week may be appropriate extremely generally, but it should be supervised & have testing done prior to treatment as you would for any TRT to know exactly what dosing may be best.