question from a user
What can you tell me about my last labs? 160mg a week at 80mg twice a week. No AI. I do take boron, zinc twice a weekly. I'm concerned about E2 and SHBG. .
AlphaMD's Answer
SHBG is produced by your liver anytime it notices that you have too much of a sex hormone (estradiol, testosterone, DHT) floating around.
Think about the testosterone you are injecting as a game where you are trying not to hit the trip wire that triggers the liver to produce more SHBG. Currently, you are injecting a large amount twice a week. We know from your levels that these two injections are above your liver's threshold so it is triggered to produce more SHBG.
The only option is to lower the dose, or split your total weekly dose into smaller injections more times a week. The more times you inject a week, the smaller your doses and the lower chance of triggering your liver to produce more SHBG. If you were to split it into 7 days a week, I can guarantee your SHBG will drop significantly.
As for your E2 being low, this is likely also a result of the SHBG being high. Remember SHBG binds to E2 just as much as T and DHT. So truly your E2 should raise if your SHBG goes down.
Try injecting the same amount, 160mg/week, but split it up daily. You can get insulin needles and do subQ injections since the volume you inject each day will be very small.
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