question from a user

What do you recommend for geneticly low SHBG guys like me? I m in great shape and train a lot, also all my blood markers are excellent; lipids, thyroid, no insuline resitance, no merabolic syndrome… before trt my shbg was at 19nmol/l and 2 months in it’s at 16nmol/l and it’s going to continue to go down since I started taking aromasin because my E2 it’s gone over the top range at 152pmol/l … I’m planning to go back on intermittent fasting and keto while upping my fibers intake and reducing my vit D intake to try to increase my shbg but I’ wondering if it’ll do anything while on TRT… FYI I’on 100mg/week splitted in 3 shots and my TT is now at 15nmol/l (was 12,9 before trt) and my FT is now at 416pmol/l (was 320 before).

AlphaMD's Answer

Managing SHBG is difficult, as there body typically tries to make more or less depending on many factors. Those changes you plan on making (fasting, keto, etc) like you are the best way to correct it non-pharmacologically. Though bear in mind high fat diets (keto) also have been shown to lower SHBG. High protein diets raise it.

Less frequent injections does typically help raise SHBG as larger steroid boluses trigger your liver to produce more SHBG.

Increasing caffeine intake has been shown to help.

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