question from a user
What do you think of e2 being more in a ratio of 3-5% of total t instead of in a range of 20-40? Just curious. In my experience, I have not had any issues with e2 being as high as 80 when total t was 1300+, but I didn’t think that would be good long term so lowered it and found sweet spot around 950-1250 total t with e2 around 40.
AlphaMD's Answer
The debate of "is it the number or the ratio" continues!
The reality is currently we do not know. There are zero scientific studies that compare the two. Estrogen level management in men for symptoms is still entirely anecdotal.
As per your anecdotal report, in your case your very high level of 80, you had no symptoms, but your T was off the charts. However, I have treated many men who had symptoms of high estrogen at a level of 35 and a total T of 550 that went away with an AI.
Which matters more, total level of E2 or ratio of T/E?
We need more studies to know.
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