question from a user
What is the ideal injection frequency for someone in the middle of the reference range for free t but, very high shgb? Is there any benefit to propionate vs cypionate for someone with high shgb?
AlphaMD's Answer
So, SHBG is released by the liver whenever it notices a bolus of sex hormones. The larger the bolus, the more it creates in an effort to buffer it (lower the free hormone level). Smaller, more frequent doses means your liver reacts less and produces less SHBG, leaving more free hormone active.
Ideal injection frequency for someone in the middle range would likely be 3 times weekly.
Propionate is released very rapidly, whereas cypionate is slowly released over time. Propionate definitely hits your liver harder and faster, making it respond in kind with higher production of SHBG.
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