question from a user
What's the half life of oestrogens? Can't find it anywhere
AlphaMD's Answer
The serum half-lifes of estrone (E1) and estradiol (E2) are about the same; 10-70 minutes.
The half-life of an estrogen after it attaches to the estrogen receptor is about 5 days.
So estrogens in the blood don’t last long, but once they attach to the receptor, they don’t travel to the liver to be broken down through hydroxylation and excreted, extending their life.
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