question from a user
Why is it that Clomid, despite raising T levels, isn't really that effective? I've seen countless people on here say that their Free and Total T levels were low, took Clomid for X months/years, their levels got back to normal/high, but they still felt like crap. Then they went on TRT and felt amazing. This has been my experience as well. Went from having low levels of Total, Free, and Bioavailable T, and after 2.5 months of Clomid all my levels are at the high end of normal, but I don't feel any different/better in any way. No noticeable improvements in any area of my life or health. So my question is: what's going on here? Why isn't Clomid very effective at actually making people feel better, despite increasing T levels? And what is the difference when taking actual exogenous T?
AlphaMD's Answer
Although we replied in the other thread, just going to post it here incase it helps someone:
People have this question often. And the answer is Clomid is a medicine, testosterone is not.What I mean by that is Clomid (clomiphene) is a foreign substance that was never meant to be inside the human body. It is a chemical, made by man, which just so happens to trigger effects on certain receptors which then trigger the body to produce hormones. All medicines have side effects, and most of them attach to receptors they are not supposed to. For example, did you know that Clomid increases testosterone, but decreases IGF-1? One of the main functions of testosterone is increasing IG-1. (A hormone beneficial for increasing protein synthesis in muscles, metabolism, and weight loss). So by taking Clomid, sure your T went up, but at the cost of reducing one of the main benefits of TRT.Testosterone is not a medicine. True, it can be prescribed, but it is not a foreign substance in your body like most medicines. The structure of testosterone given by prescription is exactly the same as what your testicles are producing. Testosterone does not attach to receptors it isn’t supposed to.
Ready to get answers?
Ask your own question today.
Get $30 off your first month’s order
Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.
Legal Disclaimer
This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.