question from a user
Why would my dose response drop so dramatically? 6 moths from start treatment: 133 mg/week. EOD frequency. Test on the morning before evening injection. No AI. TT: 1294 ng/dl. FT: 315 pg/ml SHBG: 27 nmol/L E2: 52 pg/ml HTC: 49 12 months from start of treatment: 133 mg/week. EOD frequency. Test on the morning before evening injection. No AI. TT: 830 ng/dl FT: 220 pg/ml SHBG: 20 nmol/L E2: 38 pg/ml HTC: 47 18 months from start of treatment: 154 mg/week. EOD frequency. Test on the morning before evening injection. No AI. TT: 460 FT: NA SHBG: 20 nmol/L E2 42 pg/ml HTC: 52 My dose increased, but my numbers went down, and my ratios of TT to E2 and HTC got worse. HTC was MUCH worse. This was all with the same testosterone: Alvogen. I never miss a dose. I use thin barrel syringes for dose accuracy and always do my blood test on the morning of injection day.
AlphaMD's Answer
The fact that your SHBG is dropping along with your TT and FT suggests you may have a problem with your liver’s metabolism. The liver performs over 500 different tasks, and one of those is metabolism of most medications.Remember that the ester attached to testosterone has to be cleaved before it is active. This means while testosterone is still attached to propionate, cypionate, enthanate, etc, it is inactive. Once cleaved, then it can be used by the body.If your liver isn’t doing its job of removing the ester, then it will remain inactive. The fact that your SHBG is also lowering clues us in that your liver is producing less for some reason.I have seen this occur in cases of alcoholism, autoimmune hepatitis, steatohepatitis, methotrexate use, and other hepatobiloary disorders.You definitely should follow-up with your doctor to discuss this further.
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