GONADORELIN injectable

Gonadorelin, also known as gonadotropin-releasing hormone (GnRH), is a synthetic decapeptide that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. It is used diagnostically to assess pituitary function and therapeutically to treat conditions such as delayed puberty and infertility. Pharmacokinetically, gonadorelin has a short half-life of approximately 2 to 10 minutes due to rapid enzymatic degradation by peptidases in the plasma. After intravenous or subcutaneous administration, it is quickly absorbed and metabolized, primarily in the liver and kidneys, with inactive metabolites excreted in the urine. Due to its short duration of action, continuous or pulsatile infusion is often required for sustained therapeutic effects.

Dosing:

Gonadorelin dosing varies depending on its use, whether for diagnostic testing or therapeutic treatment. The primary dosing options include:

1. Diagnostic Use (Assessing Pituitary Function):
   • A single intravenous (IV) or subcutaneous (SC) dose of 100 mcg is commonly used.
   • Blood samples for LH and FSH levels are taken at intervals (e.g., 15, 30, 45, and 60 minutes) to evaluate pituitary response.
2. Therapeutic Use (Hypogonadotropic Hypogonadism, Delayed Puberty, or Infertility):
   • 5–20 mcg subcutaneously twice daily

Side effects:

Gonadorelin is generally well-tolerated, but some common side effects may occur, including:

• Flushing
• Headache
• Nausea
• Dizziness
• Abdominal Discomfort
• Injection Site Reactions

In short:

Gonadorelin can be beneficial when used alongside testosterone replacement therapy (TRT) as it helps maintain natural testicular function by stimulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. This can prevent testicular atrophy and support endogenous testosterone and sperm production, which are often suppressed by TRT alone. Gonadorelin offers a safe alternative to traditional human chorionic gonadotropin (hCG) for those looking to preserve fertility while undergoing TRT.