HCG (Human Chorionic Gonadotropin)
Product information
$300.00
Support for Fertility, Testicular Function, and Natural Hormone Balance While on TRT
Human Chorionic Gonadotropin (hCG) is a hormone that mimics luteinizing hormone (LH), a key signal your body uses to tell the testes to produce testosterone and sperm. hCG binds more strongly to LH receptors than natural LH and remains active in your system much longer—helping maintain testicular function during testosterone replacement therapy (TRT). While natural LH only lasts about 30 minutes in the body, hCG has a half-life of around 33.5 hours and reaches peak levels in about 20 hours, which is why it's typically dosed 2 to 3 times per week.
Why hCG Is Used with TRT
When you’re on TRT, your body often reduces or stops its own LH production, which can lead to testicular shrinkage and reduced fertility. hCG helps counteract this by directly stimulating the testes—preserving intratesticular testosterone (ITT) levels, maintaining sperm production, and preventing testicular atrophy.
Research shows that:
250–375 IU/week of hCG maintains ITT at about 75% of normal
500–750 IU/week maintains it at 93%
1500 IU/week can actually raise ITT to 126% of normal
All of these doses were effective in preserving fertility and testicular size, even while on TRT.
Can hCG Reverse TRT-Related Changes?
Yes—clinical studies have shown that even after years of TRT without hCG, testicular function and fertility can often be restored by starting hCG. It doesn’t need to be used from the beginning of therapy. For many men, it can be added later and still support recovery of natural testicular activity.
Side Effects to Know
Because hCG can increase estrogen levels more than testosterone alone, some men may experience side effects such as:
Headache or mood changes (like depression or irritability)
Water retention or swelling
Breast tenderness
Local injection site discomfort
Monitoring and adjusting the dose can help manage these effects.
Other Uses of hCG
As a bridge or recovery tool for men stopping TRT or anabolic steroid use
As a standalone therapy to stimulate natural testosterone in men who aren’t candidates for TRT
Why hCG Matters
Previously, it was thought that both LH and follicle-stimulating hormone (FSH) were needed for fertility. Newer research shows that maintaining intraratesticular testosterone (ITT) is the most critical factor for preserving sperm production. Since testosterone from outside the body (like TRT) can’t enter the testes, hCG is the most effective way to keep ITT levels high and maintain fertility while on TRT.
References:
Low-dose hCG maintains ITT during TRT
In stock
