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question from a user

Can 25 mg Clomid twice a week, be enough to help prevent shrinkage with 0.5 mL of 200 mg Delatestryl once a week?

AlphaMD's Answer

Delatestryl

Yes, adding a SERM to TRT seems to reduce the likelihood of developing testicular atrophy. At least anecdotally. Concurrent use of SERMs and TRT is a new development in the men's health sphere, and as such, does not have much supporting evidence for it's use. There are several studies suggesting hCG use while on TRT for preservation of testicular volume and fertility. The same is not true for concurrent use of SERMs and TRT. There are studies on SERM monotherapy, and a few on hCG/SERM dual therapy.

If you choose to be on clomiphene along with exogenous testosterone, then you are essentially in uncharted waters. It makes sense physiologically, but long term use of SERMs has never been studied. They were designed for short term use only. Many clinics started this approach of using SERMs with TRT due to the increasing difficulty to get hCG due to some FDA regulations regarding its manufacture, whereas clomiphene is easy to find.

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