question from a user
Hearing more about demesterol levels and enclomiphene as being a long term cardiovascular risk factor. Have u looked into that at all?
AlphaMD's Answer
Desmesterol is the pre-cursor to cholesterol. Enclomiphene blocks the conversion of desmesterol into cholesterol by inhibiting the enzyme 24-dehydrocholesterol reductase. By blocking desmesterol, cholesterol levels actually drop when on enclomiphene. Technically, enclomiphene has been proven to be beneficial for heart health by reducing total cholesterol.
The problem with long term use of enclomiphene, or any of the SERMs is not concern for heart health, it is concern for two things, vision problems and decreased muscle mass. By blocking desmesterol converting into cholesterol, desmesterol deposits can build up in the eyes, causing permanent eye damage and vision loss.
Clomiphene and enclomiphene have both also been proven to block IGF-1. Since IGF-1 is is obligatory for muscle growth, and enclomiphene lowers IBG-1 levels by on average 50-60%, long term use of enclomiphene causes muscle loss.
Since muscle gain is one of the main goals of most men desiring TRT, we only recommend the use of clomiphene or enclomiphene for short periods when a man may be trying to increase his fertility.
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