question from a user
I see many people say that HCG can raise estrogen in a disproportionate amount when compared to just testosterone alone. However, I’ve never seen any studies that prove this. Do you know of any studies that do prove this, or is this strictly bro science and/or anecdotal?
AlphaMD's Answer
There are no studies on this. It is primarily something noticed clinically. For example, I saw a patient last week who was on 150mg/wk of TRT. His E2 was 35. He and his wife wanted to get pregnant so he started hCG at 1500IU/wk. His E2 after 6 weeks on that dose was 92.
This I would say is a very robust aromatization response to the addition of hCG. But in my experience, for every 500IU/wk of hCG, you can typically expect an extra 8-12 pg/mL of E2 in the average man.
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