There are no studies on this. It is primarily something noticed clinically. For example, I saw a patient last week who was on 150mg/wk of TRT. His E2 was 35. He and his wife wanted to get pregnant so ... See Full Answer
160mg a week is a great dose for Testosterone. For HCG 1500 units a week is what we would use for someone trying to actively conceive a child.A good description of HCG is that while on TRT and no HCG... See Full Answer
HCG dosing is determined independent from Testosterone levels or Testosterone dosing, and is generally based on desired use case. If your goals are cosmetic testicle size, then 250 to 500 units weekly... See Full Answer
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
Human Chorionic Gonadotropin (HCG) is a hormone most commonly associated with pregnancy, but it has important medical uses beyond fertility and reproductive health. For both men and women undergoing hormone therapy, HCG can play a key role in supporting the body’s natural hormone production—especially when it comes to testosterone. But how much does HCG actually increase testosterone? And why is it used in testosterone replacement therapy (TRT) at all? Let’s explore.
HCG is a hormone naturally produced during pregnancy. In men, it mimics the action of luteinizing hormone (LH), which signals the testes to produce more testosterone. This makes HCG particularly valuable in scenarios where natural testosterone production has been suppressed—such as during or after a course of TRT.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
Testosterone Replacement Therapy can lower or even shut down your body’s natural production of testosterone. That’s because when the brain detects an abundance of testosterone from an external source, it tells the testes to take a break. Over time, this can lead to reduced testicular size, lower fertility, and decreased sperm production.
HCG helps counter this suppression by “tricking” the body into maintaining testicular function. It sends a signal similar to LH, prompting the testes to keep producing testosterone and sperm.
The exact increase in testosterone from HCG can vary depending on several factors, including dosage, individual hormone levels, and whether HCG is used alone or alongside other therapies like TRT. However, some clinical studies offer insight:
A 2005 study published in the Journal of Clinical Endocrinology & Metabolism found that men receiving 1,500 IU of HCG three times per week had significantly elevated testosterone levels—often returning to or approaching normal range, even without additional testosterone therapy.
Another study showed that even low doses, such as 250 IU every other day, could help maintain intratesticular testosterone levels during TRT, preserving fertility and natural function.
In practical terms, patients using HCG can often see total testosterone increases of 100–300 ng/dL or more, depending on baseline levels and individual response. When combined with TRT, HCG may not significantly raise total testosterone on its own but helps maintain natural production, fertility, and overall hormonal balance.
While testosterone is typically associated with male biology, women also produce and need small amounts of testosterone for mood, energy, and libido. HCG is sometimes used in women to support hormonal balance, ovulation, or during fertility treatments. In rare cases, it may also be considered for women with low testosterone symptoms, but this should always be evaluated by a qualified provider.
HCG has proven benefits in increasing and maintaining testosterone levels, especially when used in conjunction with TRT. It can support testicular function, fertility, and a more natural hormonal balance. The exact testosterone boost varies by individual, but the hormone’s ability to preserve the body’s own production makes it a powerful tool in many TRT protocols.
If you’re considering TRT or already undergoing treatment, and want to better understand how HCG fits into your plan, AlphaMD offers online consultations with licensed providers who specialize in hormone optimization. We serve both men and women and make it easy to get expert care from the comfort of home—medications delivered directly to your door.
There are no studies on this. It is primarily something noticed clinically. For example, I saw a patient last week who was on 150mg/wk of TRT. His E2 was 35. He and his wife wanted to get pregnant so ... See Full Answer
160mg a week is a great dose for Testosterone. For HCG 1500 units a week is what we would use for someone trying to actively conceive a child.A good description of HCG is that while on TRT and no HCG... See Full Answer
HCG dosing is determined independent from Testosterone levels or Testosterone dosing, and is generally based on desired use case. If your goals are cosmetic testicle size, then 250 to 500 units weekly... See Full Answer
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