We're not the biggest fan of clomid itself. It does raise Testosterone levels but lowers IFG-1 levels, which is one of the larger benefits of having more Testosterone. Because of this you're not really getting a clear picture of what Testosterone can do for you.

Honestly, if diabetes is a result of fitness level and not genetics, I would consider getting on TRT a very good idea if that could be a result of low Testosterone. Losing weight can effect your Testosterone level, but having low Testosterone will also cause you to have high body fat to begin with depending on the severity.

If it does turn into a lifelong commitment because of how good it makes you feel to be in your normal range after tackling your fitness, I wouldn't call that a bad thing. Many people spend more on car insurance that they never use than they would on TRT which impacts a lot of things in their lives.

While we cant speak directly to the care provided by Maximus or HIMS, we have had several patients that have come to us after trying treatment with those companies. The complaints we heard from them are an impersonal experience and not having their quesions answered.

So, it should be made abundantly clear that there has never once been a long term study on use of clomid or enclomiphene for hypogonadism. That is because they are still off label use for that purpose. For that reason, we do not know the long term effects or efficacy of using SERMS.

One thing people forget is that both clomiphene and enclomiphene block IGF-1. IGF-1 is a very, very important hormone for muscle gain and fat loss. In fact, it is the primary reason you gain muscle mass with weight lifting. Blocking IGF-1 has been proven to decrease muscle mass and increase adipose tissue.

Here’s a study that shows how 6 weeks of using enclomiphene will lower IGF-1.

In the study, multiple patients’ plasma concentrations of IGF-1 decreased over 50%. Compare to another SERM, let’s say tamoxifen and clomid, plasma concentrations of IGF-1 decrease by a mean of 28.5% and 31%, respectively.

So clomid and enclomiphene are used off label for hypogonadism. They help with many of the symptoms of low T including fatigue, low libido, anxiety, and mental focus. However, they paradoxically decrease muscle mass by blocking the anabolic hormone IGF1.

TL;DR: Low testosterone causes loss of muscle mass, but clomiphene and enclomiphene causes further loss of muscle mass by blocking IGF-1 production. Higher muscle mass and lower adipose tissue prolongs life and reduces chronic disease. TRT increases both T and IGF-1 and has long term studies proving its safety and benefits to overall health and reduced incidence of disease.