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Questions about DHEA

Find answers to commonly asked questions about DHEA, administration, and benefits.

A patient asked

Would it benefit to add Dim to the protocol then and does DHEA have any effect at all on the combo? Should not even be included?

AlphaMD's answer

I would definitely try both DIM and the CD2 together. Adding DHEA can have some benefits on cognition, but usually will result in higher E2 levels thr...

A patient asked

My question is have you heard of Calcium D-glucarate being substituted instead of an AI? And reducing E levels? My Endo seems to know nothing about AI...

AlphaMD's answer

Calcium D-glucarate has been shown to increase the metabolism of estrogen, meaning your body will eliminate it from your system faster. It does nothin...

A patient asked

How do you handle libido problems? If testosterone and estradiol are both in range, where do you look next? DHT? Prolactin? I am currently dealing wi...

AlphaMD's answer

Libido issues can unfortunately be difficult to pin down sometimes because there are many factors, both intrinsic and extrinsic, that affect it.

A patient asked

Thoughts on Pregnenolone and DHEA supplementation, when it would be justified to take, dosage recommendations for the average person, symptoms of a d...

AlphaMD's answer

Pregnenolone should be supplemented any time someone is noticing mental fog or anxiety while on TRT.

A patient asked

What are the benefits of DHEA with Testosterone?

AlphaMD's answer

As of now, no DHEA receptor has been identified in the human body. That means that DHEA is solely a precursor to other sex hormones. Any DHEA you take...

A patient asked

I'm on cyp 80mg twice a week, subq. For some reason unknown to me, my E2 won't go above 15. My total test last draw was 1157 SBGH 89. Taking boron to ...

AlphaMD's answer

Add a DHEA supplement and recheck again in a month. On TRT, DHEA almost exclusively converts to estrogen.

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A patient asked

My SHBG is very low (just under reference range). My fasting sugar is middle of reference range (meaning not pre-diabetic?), I don't have cancer (in ...

AlphaMD's answer

Add a DHEA supplement and recheck again in a month. On TRT, DHEA almost exclusively converts to estrogen.

A patient asked

When these neurosteroids bottom out, would that cause adhd medications to stop working? Would introducing HCG be a better option than supplementing wi...

AlphaMD's answer

Yes, when these neurosteroids are depleted, it would make focus and attention worse. This would typically mean that any treatments for attention would...

A patient asked

Aside from high/low E2, what else are the primary reasons a person on TRT would have poor mood and low energy?

AlphaMD's answer

Hormonally speaking, it could relate to the neurosteroids pregnenolone and DHEA-S. These act directly on the brain and are associated with mood and co...

A patient asked

I see many people on this sub post with bloodwork confirming that while on TRT (test only, no HCG) all health markers look great/within range and they...

AlphaMD's answer
A patient asked

Do you typically have your patients add Pregnenolone and/or DHEA to their protocol? And if so at what dose?

AlphaMD's answer

No. Not typically. We do have some DHEA mixed into Testosterone from one vendor in particular, but that's a very low value more for compounding regula...

A patient asked

My question is have you heard of Calcium D-glucarate being substituted instead of an AI? And reducing E levels? My Endo seems to know nothing about AI...

AlphaMD's answer

Calcium D-glucarate has been shown to increase the metabolism of estrogen, meaning your body will eliminate it from your system faster. It does nothin...

A patient asked

Currently my provider has paired TRT with DHEA. What is the benefit/risk of DHEA?

AlphaMD's answer

Adding DHEA benefits:

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