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What’s your opinion or experience with Kisspeptin 10? My NP wants to run a 5 week cycle to see if it will kickstart or promote Testosterone production much the way enclomiphene would. Thanks

AlphaMD's Answer


Before saying anything, it’s important to note that kisspeptin-10 is still not FDA approved, so we can not make any medical recommendation regarding its use. We can only report on what studies have said about it.So, kisspeptin-10’s half-life is 55 seconds. This means after injection it is completely out of your system in less than 5 minutes (average is between 3.8-4.1 min). This means that it is possible that it becomes inert before it reaches the hypothalamus (where it works to increase GnRH).Even if some of it does manage to work it’s way through your entire circulatory system and attach to receptors on the hypothalamus, most of it will have degraded before then. If it does reach there and trigger the hypothalamus to release GnRH, which then causes LH release; the half life of LH is 20 minutes.20 minutes is long enough for the LH to reach the testes, but after 20 minute, it has degraded and the Leydig cells of the testes stop producing testosterone once the 20 minutes are over.The half life of enclomiphene is 10.5 hours, which means it takes over 48 hours to be fully cleared from your system. That means it releases LH that entire time. That means the Leydig cells are triggered that entire time to produce T.Long story short, if you want to waste your money on something that just gives you a very short, very small burst of testosterone, then go ahead and try kisspeptin-10. But there is a reason it is not FDA approved, and that is because it has not been proven to be effective.In theory, it would work if it didn’t degrade so rapidly.

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